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Summary of Research Projects (Supports in 2004
Fiscal Year)
| Subjects |
Bihavioral Genetic Study of Neural Function associated
with Spontaneous Locomotor Activity |
| Representative researcher |
The National Institute of Genetics (NIG)
Tsuyoshi KOIDE |
| A general activity is basic
trait related to the survival strategy and regulated by complex
genetic mechanisms. In this study, we focused on the behavioral
difference between MSM/Ms and C57BL/6, which belongs to Mus
musculus molossinus, and Mus musculus domesticus, respectively.
We tried to reveal the quantitative trait loci involved in
the difference of general activity between these strains. For
analyzing the genetic mechanism, we used the consomic strains
established from MSM/Ms and C57BL/6. The consomic strains were
established by replacing any one chromosome of C57BL/6 with
corresponding chromosome of MSM/Ms. In these strains, the traits
of B6-6CMSM, which carries chromosome 6 derived from MSM was
dramatically different in the behavior. To map the quantitative
trait loci related to the general activity on chromosome 6,
F2 population made between C57BL/6 and B6-6CMSM were analyzed
for the traits. In the result, we obtained two candidate regions.
It was reveled that the one associates with emotionality and
general activity and the other associates with general activity.
In addition to the genetic analysis, we investigated the dopamine
function by measuring extracellular dopamine in striatum. By
administrating inhibitor of dopamine transporter, we found
that the synaptic release of dopamine in striatum of B6-6CMSM
was elevated comparing with C57BL/6. |
|
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