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Subjects Development of Novel Multifunctional Organocatalysts Directed towards Supra-Enzyme
Representative
researcher		 Osaka University　Hiroaki SASAI
Two types of chiral bifunctional organocatalysts which bear Lewis base unit and Brfnsted acid unit in the single catalyst molecule have been developed to promote aza-Morita-Baylis-Hillman reaction. The suitably positioned acid-base functionalities on the catalyst molecule work synergistically to furnish the product with high enantioselectivity. In addition, we have also synthesized dendritic ligands containing two bis(imidazole) groups to develop an artificial enzyme with particular relevance to oxygen activating copper proteins. The ligand readily formed a dinuclear copper(I) complex with Cu(CH3CN)4PF6 which upon oxygenation at room temperature resulted in an intense green complex. The thermally stable complex displays spectroscopic features and reactivity patterns associated with the reported model complexes possessing a μ-η2:η2-peroxo dicopper(II) complex. The dendritic architecture is believed to enhance the thermal stability of the resulting dioxygen adduct.